Osteoporosis (OP) is a major public health problem, mainly characterized by low bone mineral density (BMD). Circulating monocytes (CMCs) may serve as progenitors of osteoclasts and produce a wide variety of factors important to bone metabolism. However, the specific action mechanism of CMCs in the pathogenesis of OP is far from clear. We performed a comparative protein expression profiling study of CMCs in Chinese premenopausal females with extremely discordant BMD, identified a total of 38 differentially expressed proteins, and confirmed with Western blotting five proteins: ras suppressor protein1 (RSU1), gelsolin (GSN), manganese-containing superoxide dismutase (SOD2), glutathione peroxidase 1(GPX1), and prolyl 4-hydroxylase β subunit (P4HB). These proteins might affect CMCs’ trans-endothelium, differentiation, and/or downstream osteoclast functions, thus contribute to differential osteoclastogenesis and finally lead to BMD variation. The findings promote our understanding of the role of CMCs in BMD determination, and provide an insight into the pathogenesis of human OP.

In order to overcome the non-uniform property of time domain signal which is obtained in the process of track irregularity detection, design a set of equidistant signal sampling system to collect signal. Use the EMD method based on the criterion of continuous mean square error de-nosing. By integrating the signal get the space trajectory of vector. Experiments show that the track irregularities detection accuracy has been greatly improved.

Mine high voltage power supply equipment on the hot temperature is too high, easy to cause the gas explosion accident, however the hot spot monitoring infrared thermometer surrounding is the existence of a large number of induced magnetic field,which influenced the temperature measurement accuracy, According to the infrared thermometer casing electromagnetic leakage, the shielding enclosure material of the infrared thermometer selected silicon steel, lens window electromagnetic leakage has become the main cause of the decline of electromagnetic shielding effectiveness. In the lens window with ITO film, after the simulation the shielding effectiveness achieves grade 50dB or above to meet the requirements of shielding effectiveness, and that improves the accuracy of temperature measurement.