In this work, new, efficient and environmentally adapted synthesis of polysubstituted imidazoles in one-pot is repoted. The multicomponent reaction of various aldehydes, benzil, aliphatic and aromatic primary amines and ammonium acetate under solvent-free condition is explained. The highly efficient role of antimony trichloride and stannous chloride dihydrate as catalyst in this synthesis was shown and their effects on the reaction process were studied. By this advantage, several polysubstituted imidazoles as pharmaceutical important molecules can be prepared in high yield and high purity. This method is a very easy and rapid for the synthesis of imidazole derivatives.
New and Rapid Access to Synthesis of Novel Polysubstituted Imidazoles Using Antimony Trichloride and Stannous Chloride Dihydrate as Effective and Reusable Catalysts. -A new and efficient and environmentally benign synthesis of the title compounds (IV),(VI) by multicomponent reaction of various aldehydes, benzil, aliphatic and aromatic primary amines and ammonium acetate under solvent--free conditions is presented. The reaction is completed within short reaction times with both catalysts whereas, somewhat better yields are mostly achieved with SbCl 3 . The catalysts can be easily recovered and reused up to five times without significant loss of activity. -(POORALI, L.; KARAMI*, B.; ESKANDARI, K.; AZIZI, M.; J. Chem. Sci. (Bangalore, India) 125 (2013) 3, 591-599, http://dx.
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