Yaşlı bir hastada düşük doz duloksetinin oluşturduğu hiponatremi Duloksetin serotonin-norepinefrin gerialım inhibitörü olup major depresyonda, stres durumlarında, idrar inkontinansında ve diyabetik nöropati veya fibromyaljiye bağlı ağrı durumlarında kullanılır. Bulantı, ağız kuruluğu, halsizlik, iştahsızlık, konstipasyon ve uykusuzluk en çok bildirilen yan etkilerdir. Duloksetine bağlı hiponatremi bizim vakamızda olduğu gibi yaşlı kadınlarda nadiren görülen bir yan etkidir. Fakat bizim vakamızı farklı kılan hasta duloksetin 30 mg/ gün kullanıyorken hiponatremi görülmesiydi.
BackgroundThe aim of this study was to compare attachment styles and psychopathology in adolescent children of parents with bipolar disorder (BD) with a healthy control group.Material/MethodsWe studied 25 adolescents who had at least 1 parent with BD (BD group) and 28 adolescents who had no parents with BD (control group). The adolescent participants were between the ages of 12 and 17 years. We used the Adolescent Relationship Scales Questionnaire (A-RSQ) for the adolescents in the BD vs. control groups, and we used the Schedule for Affective Disorders and Schizophrenia for School-age Children – present and lifetime version (K-SADS-PL). We used the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version for each parent of adolescents in the BD and control groups to rule out psychopathologies.ResultsAttachment styles of participants were assessed according to A-RSQ, dismissing attachment style scores of adolescents in BD group were found significantly higher compared to the healthy control group (p<0.05). As a result of the assessments, 12 adolescents (48%) out of 25 in the BD group and 5 adolescents (18%) out of 28 in the control group were given DSM-IV Axis I diagnosis, which is a statistically significant result (p<0.05). However, when psychiatric diagnoses were assessed separately, the difference was not statistically significant.ConclusionsWe found that the adolescent children of parents with BD have increased risk of developing mental illnesses, and that these adolescents adopt dismissing attachment styles.
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