Adenyl cyclase activity was determined in the pectoral
muscle of normal chickens and chickens with hereditary muscular
dystrophy at various stages of development. Significant differences
were found in enzyme activity between these two types of tissue.
The muscle of both normal and dystrophic embryos contained high
levels of enzyme activity which decreased shortly after hatching. By
12 weeks ex ovo enzyme titers in the normal pectoralis were sharply
reduced and remained unchanged up to 60 weeks. By contrast, enzyme levels in the dystrophic
pectoralis declined to a lesser degree after hatching and then rose sharply beginning
at 12 weeks ex ovo and remained high in the mature bird. Cyclic AMP phosphodiesterase
activity levels were altered in a similar manner in the two tissues.
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