ObjectiveThe aim of the study was to report the proportion of homozygous and compound heterozygous variants in the survival motor neuron 1 (SMN1) gene in a large population of patients with spinal muscular atrophy (SMA) and to correlate the severity of the disease with the presence of specific intragenic variants in SMN1 and with the SMN2 copy number.MethodsFour hundred fifty Brazilian patients with SMA were included in a retrospective study, and clinical data were analyzed compared with genetic data; the SMN2 copy number was obtained by multiplex ligation-dependent probe amplification and pathogenic variants in SMN1 by next-generation sequencing.ResultsFour hundred two patients (89.3%) presented homozygous exon 7-SMN1 deletion, and 48 (10.7%) were compound heterozygous for the common deletion in one allele and a point mutation in the other allele. Recurrent variants in exons 3 and 6 (c.460C>T, c.770_780dup and c.734_735insC) accounted for almost 80% of compound heterozygous patients. Another recurrent pathogenic variant was c.5C>G at exon 1. Patients with c.770_780dup and c.734_735insC had a clinical phenotype correlated with SMN2 copy number, whereas the variants c.460C>T and c.5C>G determined a milder phenotype independently of the SMN2 copies.ConclusionsPatients with specific pathogenic variants (c.460C>T and c.5C>G) presented a milder phenotype, and the SMN2 copy number did not correlate with disease severity in this group.
Recently, evaluation of organizational climate has been considered an important management tool in health institutions. The aim of this study was to evaluate the organizational climate and its relationship with the occurrence of accidents with needlestick materials among nursing professionals in a public hospital of medium complexity in the state of São Paulo. It is a study of quantitative, descriptive and cross-sectoral approach. The instrument Safety Attitudes Questionnaire (SAQ) was used-Short Form, 2006, validated and adapted version for the Portuguese language (Safety Attitudes Questionnaire-QAS). Through the areas of QAS was possible to assess attitudes about the working environment in staff, safety climate, job satisfaction, perceived stress, management actions regarding safety issues and working conditions. The answers were given by Likert scale of five points, processing and data analysis was performed with the aid of the Statistical Package for Social Sciences (SPSS) version 17.0. To relate the organizational climate with the occurrence of accidents with sharps survey was carried out by the Specialized Service of Medicine and Safety-SESMT with records of work accidents in the period 2008-2014 and workers were identified nursing victims of these accidents. Constituted two groups: Group 1-nursing professionals who were victims of work accidents involving sharps; Group 2-nursing professionals who did not undergo occupational accidents with needlestick during the study period. After conformal groups, the data analysis was performed using descriptive statistics with correlation tests between the variables of the groups in order to analyze possible relationship between accidents and the adoption of safety measures by the professional. The study sample consisted of 116 participants, nursing technicians and nurses working in hospital units. Group 1 consisted of 21 participants and Group 2 consists of 95 participants. Predominated female participants, nursing technicians and professionals with five to 10 years of experience in this institution. The perception of the participants about the organizational climate was considered unfavorable, however it was observed that job satisfaction was evidenced by most of the participants, demonstrating how they feel during the exercise of the profession in this institution. On the relationship between organizational climate and the occurrence of accidents with needlestick materials, the results indicated no direct relationship between organizational climate and the occurrence of such accidents, however it was observed that the group that did not suffer sharps injuries was the group that presented greater job satisfaction. Thus, this study promotes the opportunity to meet the professionals' perception of the organizational climate and can contribute to improvement of safe care, reduce adverse events and improve the quality of patient care.
Extrafloral nectaried plants and myrmecophytes offer resources to ants that may engage in protective mutualisms. The role of different ant species in herbivore deterrence has long been analyzed by using herbivore baits, and ants are regarded as effective plant guards if they attack and/or remove the baits (mostly termites) from plants. Here, we conducted a comparative investigation on which ants display aggression toward baits, which ants are better plant guards, and which plants (extrafloral nectaried plants or myrmecophytes) are better defended by ants. Data from the literature revealed that baiting studies have been performed on 37 extrafloral nectaried plant species and 19 myrmecophytes, and have involved over 30 genera of ants. Extrafloral nectaried plants and myrmecophytes rely on specific ant fauna to defend them from herbivores. In extrafloral nectaried plants,CamponotusandCrematogasterwere regarded as the best plant protectors, as they attacked baits in nearly all plants. In myrmecophytes,Azteca, PheidoleandPseudomyrmexwere the most important bait attackers. Myrmecophytes were better protected by ants, as all baits were attacked; in extrafloral nectaried plants, some ants failed to attack the baits. Plants can be patrolled by several different ants, but there is a core of ants that excel in protection, and this varies according to plant type (extrafloral nectaried plants and myrmecophytes). With this knowledge, it may be possible to label different ants as effective plant guards, to anticipate their effects on plant performance and even to understand their potential role as biological control agents.
Resumo: Estudo quantitativo, descritivo e transversal, realizado com o objetivo de avaliar o clima organizacional de um hospital público do Estado de São Paulo e a sua relação com a ocorrência de acidentes de trabalho com perfurocortantes entre os profissionais de enfermagem. Para a coleta dos dados, foi utilizada a versão em português Organizational climate and the occurrence of accidents by sharp objects in a public hospital in the State of São PauloAbstract: A Quantitative, descriptive and cross-sectional study, conducted with the aim to evaluating the organizational climate of a public hospital in the State of São Paulo and its relationship with the occurrence of occupational injuries by sharp objects among nursing professionals. Data were collected using the Portuguese version of the Safety Attitudes Questionnaire (SAQ). In order to correlate the organizational climate to the occurrence of work accidents the participants were divided into two groups: Group 1 -nursing workers who suffered occupational accidents by sharp objects; Group 2 -nursing professionals who did not undergo occupational accidents with needlestick. Data analysis was performed using descriptive statistics with a correlation test between the group's variables. The study sample consisted of 116 participants; which 21 were in group 1 and 95 in group 2. Participants were mostly female, nursing technicians and professionals with 5 to 10 years of experience in this institution. The perception of the participants about the organizational climate was considered unfavorable; however, most participants reported Clima organizacional e ocorrência de acidentes com materiais perfurocortantes em um hospital público do Estado de São Paulo
Objetivamos analisar as produções científicas nacionais sobre o suicídio segundo as psicologias humanista, fenomenológica e existencial. Foi utilizado o método de revisão sistemática seguido de uma metassíntese qualitativa dos achados. Computamos 18 artigos categorizados e analisados conforme título, autoria, base de dados, periódico, ano de publicação, área de discussão, tipo de estudo, objetivos e resultados. Os resultados demonstram: proeminência de produções na Revista da Abordagem Gestáltica; concentração de publicações no PePSIC; aglomeração de produções na última década, em razão das políticas de prevenção ao suicídio; expressividade de produções filiadas à UFRN; concentração de estudos empíricos norteados pelo método fenomenológico e influenciados por Heidegger. Os achados foram sintetizados segundo: as relações entre psicopatologia e suicídio; os motivos e explicações sobre o suicídio; o pensamento fenomenológico-existencial acerca do suicídio; as práticas e intervenções humanista, fenomenológica e existencial no tratamento. Concluímos que os estudos consideram as tradicionais perspectivas biomédicas de pensamento e manejo do suicídio, contudo tentam repensar isso com base em lentes clínicas mais subjetivas e compreensivas. Palavras-chave: suicídio; fenomenologia; psicologia humanista.
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