Introduction: Solvatochromic dyes are probes to detect variations on the dipole moment of solvents after the insertion of homeopathic potencies. Recent studies have shown they can be useful tools in laboratory and field studies to detect the activity of homeopathic remedies. Objective: Determine whether solvatochromic dyes can be a diagnostic tool for cells infected by different agents and/or markers to identify the activity of homeopathic medicines. Methods: Ethilicum 1cH, Silicea terra 6, 30, 200cH; Zincum metallicum 6, 30, 200cH and Phosphorus 6, 30 and 200cH were analyzed by pouring the samples (in a 1:60 rate) into a series of seven dyes (rhodamine, ET 33, ET 30, coumarin 7, NN DMIA, Nile red, methylene violet) diluted in absolute ethanol using pre-established working concentrations. Oscillations of dye absorbance were observed at visible light spectrophotometry according to the remedy and potency. Water and succussed water were used as controls. In a second moment, the absorbance profile of the remedies will be compared with those of biological samples (supernatants) and checked with the biological effect previously obtained from each treatment. Supernatants of RAW 264.7 macrophages stimulated by Calmette-Guérin bacilli (BCG) or infected with Encephalitozoon cuniculi will be analyzed. Results: Preliminary results have shown that Silicea terra 6cH, Phosphorus 30 and 200cH and Zincum metallicum 6, 30 and 200cH reduced the absorbance of methylene violet (p=0.01). Repetitions and analysis of supernatants are expected to be performed in the next steps of the study. Future perspectives: Establish a pattern of reactivity of the studied medicines with different dyes and the putative relation with the corresponding supernatants, as an attempt to obtain a “physicochemical signature” for each kind of infection and/or treatment.
Innovations in homeopathy researchThe Editorial team of the International Journal of High Dilution Research is happy to announce the publication of a new number published in 2019.The content of this number includes two original research in nosodes. In first place, the paper published by Shah et al describe the production of new cancer nosodes, available for research. The first cancer nosodes were developed by Dr. J. C. Burnett, including Carcinosin. The poor characterization of the histological descriptions of that time, make the reproduction of carcinosin and other cancer nosodes difficult. New, more specific and better characterized nosodes will make easier to reproduce the research results. In other paper, R. Shah shows the evaluation of the anticancer effect of different types of nosodes of cancer or viral origin applied over different cell lines.An interesting and growing field in the evaluation of the effect of homeopathic preparations is Agrohomeopathy. In this number a third article from Pereira Bonfim et al describes the protective effect of Natrum muriaticum dilution in tomato seedlings against saline stress.With this number, the International Journal of High Dilution Research is starting with a fresh Editorial team that will try in the coming years to grow and improve the quality of the information about research in Homeopathic dilutions. Research in Homeopathy, despite misleading media information, is growing in quality and in size. The IJHDR editorial team will thrive to provide our readers with cutting edge basic and clinical research with the advantage of the open access policy.
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