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The Roofline model graphically represents the attainable upper bound performance of a computer architecture. This paper analyzes the original Roofline model and proposes a novel approach to provide a more insightful performance modeling of modern architectures by introducing cache-awareness, thus significantly improving the guidelines for application optimization. The proposed model was experimentally verified for different architectures by taking advantage of built-in hardware counters with a curve fitness above 90%.

It is unlikely that a hacker is able to compromise sensitive data that is stored in an encrypted form. However, when data is to be processed, it has to be decrypted, becoming vulnerable to attacks. Homomorphic encryption fixes this vulnerability by allowing one to compute directly on encrypted data. In this survey, both previous and current Somewhat Homomorphic Encryption (SHE) schemes are reviewed, and the more powerful and recent Fully Homomorphic Encryption (FHE) schemes are comprehensively studied. The concepts that support these schemes are presented, and their performance and security are analyzed from an engineering standpoint.

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This paper presents a prototype of a platform for biomolecular recognition detection. The system is based on a magnetoresistive biochip that performs biorecognition assays by detecting magnetically tagged targets. All the electronic circuitry for addressing, driving and reading out signals from spin-valve or magnetic tunnel junctions sensors is implemented using off-the-shelf components. Taking advantage of digital signal processing techniques, the acquired signals are processed in real time and transmitted to a digital analyzer that enables the user to control and follow the experiment through a graphical user interface. The developed platform is portable and capable of operating autonomously for nearly eight hours. Experimental results show that the noise level of the described platform is one order of magnitude lower than the one presented by the previously used measurement set-up. Experimental results also show that this device is able to detect magnetic nanoparticles with a diameter of 250 nm at a concentration of about 40 fM. Finally, the biomolecular recognition detection capabilities of the platform are demonstrated by performing a hybridization assay using complementary and non-complementary probes and a magnetically tagged 20mer single stranded DNA target.