Type 2 diabetes (T2D) is a multisystem disease that is the subject of many studies, but the earliest cause of the disease has yet to be elucidated. Mitochondrial impairment has been associated with diabetes in several tissues. To extend the association between T2D and mitochondrial impairment to blood cells, we investigated T2D-related changes in peripheral mononucleated blood cells’ (PBMCs) mitochondrial function in two groups of women (CTRL vs. T2D; mean age: 54.1 ± 3.8 vs. 60.9 ± 4.8; mean BMI 25.6 ± 5.2 vs. 30.0 ± 5), together with a panel of blood biomarkers, anthropometric measurements and physiological parameters (VO2max and strength tests). Dual-energy X-ray absorptiometry (DXA) scan analysis, cardio-pulmonary exercise test and blood biomarkers confirmed hallmarks of diabetes in the T2D group. Mitochondrial function assays performed with high resolution respirometry highlighted a significant reduction of mitochondrial respiration in the ADP-stimulated state (OXPHOS; −30%, p = 0.006) and maximal non-coupled respiration (ET; −30%, p = 0.004) in PBMCs samples from the T2D group. The total glutathione antioxidant pool (GSHt) was significantly reduced (−38%: p = 0.04) in plasma samples from the T2D group. The fraction of glycated hemoglobin (Hb1Ac) was positively associated with markers of inflammation (C-reactive protein-CRP r = 0.618; p = 0.006) and of dyslipidemia (triglycerides-TG r = 0.815; p < 0.0001). The same marker (Hb1Ac) was negatively associated with mitochondrial activity levels (OXPHOS r = −0.502; p = 0.034; ET r = −0.529; p = 0.024). The results obtained in overweight postmenopausal women from analysis of PBMCs mitochondrial respiration and their association with anthropometric and physiological parameters indicate that PBMC could represent a reliable model for studying T2D-related metabolic impairment and could be useful for testing the effectiveness of interventions targeting mitochondria.
Microphone arrays of various sizes and shapes are widely employed in consumer electronics devices such as smart speakers, speakerphones, smart TVs, smartphones, PCs, and headphones. Therefore, the possibility of creating arrays of arrays (i.e., meta-arrays), by easily connecting several smaller units, is particularly interesting: it allows for different shapes, with an increased number of microphones and improved performance, while keeping costs low. In this paper, full-digital microphone meta-arrays are presented: they are constituted by an arrangement of several triangular units, each featuring four digital Micro Electro-Mechanical Systems (MEMS) capsules connected in daisy-chain through the Automotive Audio Bus (A 2 B). Two prototypes have been built: a planar meta-array made of seven triangles (28 capsules) and a 3-dimensional meta-array with 14 triangles (56 capsules). Numerical simulations were carried out and compared against experimental measurements performed on the prototypes, showing an excellent matching. Finally, the 3-dimensional meta-array was compared with a spherical microphone array widely considered the state-of-the-art equipment in the last decade, demonstrating its potential in telecommunication applications.
In a multiple parallel-connected inverters system, limiting the circulating current phenomenon is mandatory since it may influence efficiency and reliability. In this paper, a new control method aimed at this purpose and conceived to be implemented on a Field Programmable Gate Array (FPGA) device is presented. Each of the inverters, connected in parallel, is conceived to be equipped with an FPGA that controls the Pulse-Width Modulation (PWM) waveform without intercommunication with the others. The hardware implemented is the same for every inverter; therefore, the addition of a new module does not require redesign, enhancing system modularity. The system has been simulated in a Simulink environment. To study its behavior and to improve the control method, simulations with two parallel-connected inverters have been firstly conducted, then additional simulations have been performed with increasing complexity to demonstrate the quality of the algorithm. The results prove the ability of the method proposed to limit the circulating currents to negligible values.
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