(Spon. by F r e d e r i c k C. B a t t a g l i a ) U n i v e r s i t y of Colorado Medical Center, D i v i s i o n of P e r i n a t a l Medicine-Depts of P e d i a t r i c s , O b s t e t r i c s -G y n e c o l o g y a n d Physiology, Denver, Colorado.Eight sheep f e t u s e s (125-140 days o l d ) were c h r o n i c a l l y cathet e r i z e d and infused w i t h 20-25 mEq/Kg of NH C1 i n o r d e r t o study 4 t h e e f f e c t s of a c u t e metabolic acidemia on t h e f e t a l c i r c u l a t i o n . The f e t a l a r t e r i a l pH decreased from 7.4-7.35 t o 6.8-6.9. Regiorr a 1 blood flows b e f o r e and d u r i n g acidemia were measured by means of a microsphere method. During NH C1 acidemia, 819 animals showed i n c r e a s e d blood flow t o t h e Aiaphragm and t o t h e i n t e rc o s t a l muscles.I n subsequent p r e p a r a t i o n s , t r a c h e a l and amnio t i c c a t h e t e r s were placed and t h e s e showed t h a t NH4C1 induced r e g u l a r r e s p i r a t i o n s (60-90/min) g e n e r a t i n g n e g a t i v e t~a c h e a l p r e s s u r e s of 20-30 t o r r . Regular b r e a t h i n g began 1-2 h o u r s a f t e r s t o p p i n g t h e i n f u s i o n of NH4C1 and continued f o r 1 2 -2 4 h o u r s -a ft e r blood ammonia c o n c e n t r a t i o n s had r e t u r n e d t o normal. Repeated i n f u s i o n s of NH C1 e l i c i t e d t h e same response. Pulmonary blood flows were higher a t s i m i l a r r i g h t v e n t r i c u l a r P0;s d u r i n g NH C1-induced acidemia. A l l f e t u s e s had normal blood p r e s s u r e a n 2 h e a r t r a t e , and a l l recovered completely.ml.min-l. 100 gm-l + SEM l d i a p h r a g m blood flow l i n t e r c o s t a l muscles blood f l o C o n t r o l I ) antigens i n the serum o f p a t i e n t s w i t h CF. Forty-six CF p a t i e n t s o f v a r y i n c l i n i c a l severity(age 5-46yrs. )were studied f o r evidence o f : ( l q r e s p i r a t o r y c o l o n i z a t i o n w i t h Asp, (2)bronch pulmonary a l l e r g i c a s p e r g i l l o s i s (BPAA), and (3) atopy.Asp. was c u l t u r e d from sputums o f 46%(21/46) o f p a t i e n t s . A l a b o r a t o r y i s o l a t i o n r a t e o f 6.5%(20/305) was found i n r e s p i r at o r y specimens o f non-CF p a t i e n t s (p
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