Following the implantation of adrenocorticotrophin-producing tumors into LAF1 mice, a reproducible syndrome was observed which was characterized by adrenal cortical hypertrophy, thymic atrophy, lymphopenia, ovarian atrophy, cessation of estrus cycles, obesity, polydipsia, and polyuria. These changes appeared after intervals of a few weeks or several months, depending on the secretory activity of the tumor. Metabolic balance studies indicated an increased excretion of nitrogen and potassium. In place of an intolerance to glucose in the tumor-bearing mice, there was an apparently increased tolerance, presumably due to the presence of the large tumor mass. Observations on intact, castrated, and hypophysectomized mice bearing ACTH tumors suggested that the C21 steroids of LAF1 mice possess moderate glucocorticoid as well as discernible mineralocorticoid activity; the C19 steroids apparently are either very weak or inactive androgens, but may be capable of directly affecting the anterior pituitary and the vagina.
Following the implantation of adrenocorticotrophin-producing tumors into LAF1 mice, a reproducible syndrome was observed which was characterized by adrenal cortical hypertrophy, thymic atrophy, lymphopenia, ovarian atrophy, cessation of estrus cycles, obesity, polydipsia, and polyuria. These changes appeared after intervals of a few weeks or several months, depending on the secretory activity of the tumor. Metabolic balance studies indicated an increased excretion of nitrogen and potassium. In place of an intolerance to glucose in the tumor-bearing mice, there was an apparently increased tolerance, presumably due to the presence of the large tumor mass. Observations on intact, castrated, and hypophysectomized mice bearing ACTH tumors suggested that the C21 steroids of LAF1 mice possess moderate glucocorticoid as well as discernible mineralocorticoid activity; the C19 steroids apparently are either very weak or inactive androgens, but may be capable of directly affecting the anterior pituitary and the vagina.
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