Reteplase, when given as a double bolus of 10 plus 10 megaunits to patients with acute myocardial infarction, achieves significantly higher rates of early reperfusion of the infarct-related coronary artery and requires significantly fewer acute coronary interventions than front-loaded alteplase without an apparent increased risk of complications.
Serial volumetric IVUS revealed that the RADIUS stents continued to enlarge during the follow-up period. In this stent implantation protocol, this expansion was accompanied by a greater amount of neointima than the Palmaz-Schatz stents, resulting in similar late lumen loss in both configurations. In the peristent margins, however, late lumen loss was minimized with the RADIUS stents.
Recently, ergonovine has been suggested to evoke coronary artery spasm in patients with variant angina. The purpose of our investigation was to study clinical, hemodynamic, electrocardiographic (ECG), and coronary angiographic effects of ergonovine in 60 selected patients undergoing angiography. The patients were equally divided, 30 with coronary artery disease (CAD), lesions 250%, and 30 with minimal (<50%) or no CAD. Ergonovine (0.05 to 0.4 mg i.v. bolus) was given while each patient was monitored for symptoms and changes in ECG, heart rate, QTc intervals, blood pressure, and coronary diameter. After ergonovine, 18 patients developed chest pain, eight of whom had associated STsegment shifts (>-I mm). Heart rate and QTc showed no significant change. Systolic blood pressure increased from 133 mm Hg (mean) to
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