Nitroso-Diels-Alder (NDA) reaction is used as a tool for the synthesis of 3,6-dihydro-1,2-oxazine derivatives, which are important intermediates in the synthesis of natural products and biologically active compounds. In this work, we investigated the enantioselective version of this reaction on a solid support.We studied various catalysts, concentrations, temperatures and solvents and compared them with the best conditions reported for solution-phase chemistry. The best conditions were also applied to other 1,2-oxazine derivatives.
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