Microfluidics has emerged as a powerful technology with diverse applications in microbiology, medicine, chemistry, and physics. While its potential for controlling and studying chemical reactions is well recognized, the extraction and utilization of the vast amounts of high-quality information generated within microfluidic devices remain challenging. This is mainly due to the limited tools available for in situ measurements of chemical reactions. In this study, we present a proof-of-concept spectIR-fluidic reactor design that combines microfluidics with Fourier transform infrared (FTIR) spectroscopy for in situ kinetic studies of fast reactions. By integrating a multi-ridge silicon attenuated total reflection (ATR) wafer into the microfluidic device, we enable multi-point measurements for precise reaction time monitoring. This work establishes a validated foundation for studying a wide range of chemical reactions using ATR-FTIR spectroscopy, which will enable simultaneous quantification of reagents, intermediates, and products. The spectIR-fluidic platform offers customizable designs, allowing for the investigation of reactions with various time scales, and has the potential to significantly advance reaction optimization and pathway exploration.
Com o surgimento da pandemia de SARS-COV-2 em 2019, surgiram muitas dúvidas e incertezas sobre a doença COVID-19, muitas delas devido aos milhares de fake-news, falta de informações, poucas pesquisas científicas que comprovassem os desdobramentos do que realmente iria acontecer, desde os sintomas, formas de contágio, como cada organismo reagiria ao vírus, sobre a eficácia das máscaras e do isolamento social, mas principalmente sobre os tratamentos contra o novo coronavírus. Com todas essas dúvidas, algumas medidas foram tomadas para tentar amenizar e resolver a situação. O chamado “KIT-COVID” (contendo medicamentos, dentre eles estão antibióticos) e hoje não recomendado pelo Ministério da Saúde, foi uma das medidas controversas que ocorreram no Brasil. A recomendação do uso de medicamentos sem eficácia comprovada cientificamente contra os sintomas da COVID-19, fez com que as vendas de medicamentos antimicrobianos dobrassem em diferentes locais do país, inclusive na cidade de Nanuque, MG, como demostrado nesse estudo. Esse aumento da utilização dos antibióticos torna-se preocupante, pois aumenta a probabilidade de casos de resistência microbiana, transformando bactérias comuns, em possíveis superbactérias, fazendo-se necessário a utilização de antibióticos cada vez mais potentes.
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