consistently failed to elicit deciduomata in 70 ovariectomized mice not subjected to uterine traumatization.The mouse is apparently capable of producing progesterone in amounts equivalent to 1.0 mg injected daily ;6 and the equivalent of the smaller injected amounts is assuredly produced normally by the ovaries of the mouse during pregnancy, pseudopregnancy, and lact a t i~n .~? Moreover, the long period after ovariectoniy precludes any direct involvement of estrogen as such in these reactions, and presumably also rules out any preparatory action of this hormone. Thus, without the recent or simultaneous action of estrogen, progesterone in physiologic amounts is capable of eliciting the development o f placen tomat a in the suit ably traumatized uterus of the mouse.
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