(18)F-Flutemetamol performs similarly to the (11)C-PIB parent molecule within the same subjects and provides high test-retest replicability and potentially much wider accessibility for clinical and research use.

Care should be taken when applying PVC to amyloid PET images. Assumptions made in existing PVC strategies can induce biases that could lead to erroneous inferences about uptake in certain regions. The proposed RBV PVC technique accounts for within-compartment variability, with the potential to reduce errors of this kind.

No abstract

Background: Gantenerumab is a fully human anti-A␤ monoclonal antibody in clinical development for the treatment of Alzheimer disease (AD). Objectives: To investigate whether treatment with gantenerumab leads to a measurable reduction in the level of A␤ amyloid in the brain and to elucidate the mechanism of amyloid reduction. Design: A multicenter, randomized, double-blind, placebo-controlled, ascending-dose positron emission tomographic study. Additionally, ex vivo studies of human brain slices from an independent sample of patients who had AD were performed.

No abstract