Somatosensory evoked potentials (SSEPs) are a viable way to measure processing of somatosensory information. SSEPs have been described at the scalp and the cortical level by electroencephalographic, magnetoencephalographic and intracranial cortical recordings focusing on short-latency (SL; latency<40 ms) and long-latency (LL; latency>40 ms) SSEPs as well as by deep brain stimulation (DBS) electrode studies targeting SL-SSEPs. Unfortunately, LL-SSEPs have not been addressed at the subcortical level aside from the fact that studies targeting the characteristics and generators of SSEPs have been neglected for the last ten years. To cope with these issues, we investigated LL-SSEPs of the subthalamic nucleus (STN) in twelve patients with Parkinson’s disease (PD) that underwent deep brain stimulation (DBS) treatment. In a postoperative setting, LL-SSEPs were elicited by median nerve stimulation (MNS) to the patient’s wrists. Ipsilateral or contralateral MNS was applied with a 3 s inter-stimulus interval. Here, we report about four distinctive LL-SSEPs (“LL–complex” consisting of P80, N100, P140 and N200 component), which were recorded by using monopolar/bipolar reference and ipsi/contralateral MNS. Phase reversal and/or maximum amplitude provided support for the generation of such LL-SSEPs within the STN, which also underscores a role of this subcortical structure in sensory processing.
There are multiple errors throughout the paper. In the second paragraph of the introduction, reference [10] is incorrectly placed after the third sentence. It should be placed after the fourth sentence and read as follows: On the other hand, LL-SSEPs possess latencies greater or equal to 40 ms [10].The first sentence of the Monopolar reference section is missing the phrase "by controlateral MNS," after the word elicited. The correct sentence is: With regard to SL-SSEPs, a component with mean latency 18.9±1.2 ms and mean amplitude 2.7±1.9 μV was elicited by contralateral MNS in twenty-two out of twenty four STN's.The first sentence of the third paragraph within the Discussion section incorrectly references the VIM as being independent from the thalamus. The correct sentence is: Focusing on the generators of SL-SSEPs, previous studies directed towards the thalamus [18] and its VIM [20, 21] came to different conclusions regarding the generators of SL-SSEPs.
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