Nanosuspension prepared with MBA showed rapid treatment in comparison with other nano formulations. The formulation also showed higher anti-inflammatory activity for a longer duration compared to aqueous suspension of the drug, which is due to small particle size and mucoadhesiveness of polymeric micelles.
Visual loss after nonocular surgery is rare but devastating. Peak rates of perioperative visual loss are with heart and spine surgery. The two possible main causes of visual loss after cardiac surgery are ischemic optic neuropathy and retinal ischemia due to embolism and / or low perfusion secondary to hemodynamic changes through cardiopulmonary bypass within the retinal, optic nerve and choroidal circulation. Stable preservation of some hemodynamic factors during cardiac surgery seems to be the key to stop visual loss. The purpose of this article is to briefly review perioperative visual loss after cardiac surgery.
Introduction: Behcet's disease (BD) is a multi-systemic inflammatory disorder. Evaluating the production of cytokines such as interferon gamma and biomarkers such as heat shock protein-70 (HSP70)is an important way to study the pathogenesis and development of BD. This study aimed to compare the salivary level of interferon gamma and HSP70 between patients infected with BD and healthy individual. Methods: This case-control study was performed on 35 patients with Behcet's syndrome and 70 healthy individuals as the control group, who were selected from those referring to the Department of Oral Medicine of Tabriz University of Medical Sciences. The levels of interferon gamma and HSP70 were measured in the whole unstimulated saliva through enzyme-linked immunosorbent assay (ELIZA). In order to compare the quantitative variables between two groups, independent samples t-test or its nonparametric equivalent, Mann-Whitney U test, was used in SPSS software version 16.0. In this study, a P value less than 0.05 was considered statistically significant. Results: There was no significant difference between the study groups in terms of age and gender, as well as salivary interferon gamma and HSP70 levels. Interferon gamma level was 15.16 ± 3.38 pg/mg in the case group and 5.27 ± 1.21 pg/mg in the control group, and salivary HSP70 level was found to be 45.50 ± 17 ng/mL and 19.5 ± 5.2 ng/mL in the case and control groups, respectively. Conclusions: The results of this study showed that interferon gamma and HSP70 levels in patients with Behcet's syndrome are high and can be evaluated as an important tool for the treatment and evaluation of disease development in future studies.
Background: Cystoid macular edema (CME) is the leading cause of permanent visual impairment in patients with uveitis, particularly in patients with intermediate uveitis (IU). This study was aimed at comparing the changes in the macular microvasculature in patients with IU with uveitic non-responsive CME and without macular edema.
Methods: In this case-control study, 55 eyes of patients with IU were assessed for macular microvascular structures, including vascular density, foveal avascular zone (FAZ) measurement, and vascular morphological changes, using spectral-domain optical coherence tomography angiography (OCT-A) with the AngioVue OCT-A system. We divided patients into the following two groups: the case group, including 30 eyes with IU-related non-responsive CME, and the control group, including 25 eyes with IU without macular edema.
Results: Participants in the case and control groups had comparable age (P = 0.753) and sex (P = 0.124) distributions. Superficial capillary plexus vessel density in the case group was significantly decreased in the whole image (P = 0.027) and the parafoveal area (P = 0.001) compared to the control group. However, there were no statistically significant differences between the two groups in terms of foveal superficial vessel density, deep capillary plexus vessel density, FAZ area, FAZ perimeter, FAZ acircularity index, or foveal vessel density in a 300-µm-wide annulus around the FAZ (all P > 0.05). Vascular morphological changes, such as the capillary tuft, telangiectatic vessels, or micro-aneurism, were not different in the overview images of the OCT-A printout between the two groups.
Conclusions: The mean superficial capillary plexus vessel density was lower in eyes with IU-related nonresponsive CME than in those without macular edema. We observed more cystoid spaces in SCP than in DCP. Microcystic changes in the inner retina and ischemia may be the underlying cause in eyes with nonresponsive CME. Future prospective longitudinal studies with healthy, matched controls are warranted to confirm our findings.
Objective : To assess the microvascular structure of macula in uveitic refractory macular edemaMethod:In a cross-sectional observational study fifty-five patients in all were assessed for macular microvascular structure using Optuve OCT angiography: 30 patients with intermediate uveitis-related refractory macular edema (RME group), and 25 patients with intermediate uveitis without macular edema (control group).Results:Superficial layer density in RME and control group were significantly different in whole image and parafovea (P=0.027 , P= 0.001), however there was no significant differences between the two groups in fovea superficial density (P=0.711).There was no significant difference in deep layer density between the two groups (P>0.05).Conclusion:The density of superficial vessels is lower in refractory macular edema. Micro-cystic changes in inner retina and ischemia can be the cause of alteration in superficial layer density in refractory macular edema.
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