Background: The quality of marital relationship is affected by several factors. This study aimed to examine the role of personality factors in the relationship between family-of-origin health status and marital adjustment. Methods: This study is of descriptive method and the design is correlational based on path analysis. The study population consisted of all married men and women in Qazvin who spent at least one year of their marriage. Accordingly, 300 married adults (150 men and 150 women) were selected via available sampling method and participated in the study. Data were analyzed using structural equation modeling and Bootstrap test in the Amos software. The conceptual model of the family of origin health status, personality factors and marital adjustment had goodness of fit. Results: The results of structural equation modeling suggested that family-of-origin health status is directly related to marital adjustment (β=0.490, P<0.01). In addition, Bootstrap test showed that personality factors-neuroticism (β=0.461, P<0.001), extraversion (β=0.455, P<0.005), agreeableness (β=0.452, P<0.001) and conscientiousness (β=0.448, P<0.001) have indirect effect in the relationship between family-of-origin health status and marital adjustment. Conclusion: Based on the results, it can be said that individual's experiences from the family-oforigin and personality factors may be associated with better or worse levels of marital adjustment.
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