No abstract

Whether initiation of statins could increase survival free of dementia and disability in adults aged ≥75 years is unknown. PREVENTABLE, a double‐blind, placebo‐controlled randomized pragmatic clinical trial, will compare high‐intensity statin therapy (atorvastatin 40 mg) with placebo in 20,000 community‐dwelling adults aged ≥75 years without cardiovascular disease, disability, or dementia at baseline. Exclusion criteria include statin use in the prior year or for >5 years and inability to take a statin. Potential participants are identified using computable phenotypes derived from the electronic health record and local referrals from the community. Participants will undergo baseline cognitive testing, with physical testing and a blinded lipid panel if feasible. Cognitive testing and disability screening will be conducted annually. Multiple data sources will be queried for cardiovascular events, dementia, and disability; survival is site‐reported and supplemented by a National Death Index search. The primary outcome is survival free of new dementia or persisting disability. Co‐secondary outcomes are a composite of cardiovascular death, hospitalization for unstable angina or myocardial infarction, heart failure, stroke, or coronary revascularization; and a composite of mild cognitive impairment or dementia. Ancillary studies will offer mechanistic insights into the effects of statins on key outcomes. Biorepository samples are obtained and stored for future study. These results will inform the benefit of statins for increasing survival free of dementia and disability among older adults. This is a pioneering pragmatic study testing important questions with low participant burden to align with the needs of the growing population of older adults.

No abstract

Robot integration in railway maintenance steps a prominent pavement in high-efficient and low-cost job execution for the infrastructure management. To achieve practical and diverse inspection and repair railway job, a robot manipulator on a locomotive platform is one of the best options. A lot of research has been conducted to find the accuracy and precision of industrial robotic manipulator where the manipulator base is fixed. This paper initiates an exploration of the accuracy and precision of a Robotic Inspection and Repair System (RIRS), which is a novel robotic railway maintenance system integrated with an industrial manipulator (UR10e) with 6 degree-of-freedom, mounting on an Unmanned Ground Vehicle (UGV) (Warthog) and specially designed trolley. In this research, a mimic track visual inspection test using QR code detection is adopted and implemented by an arm-mounted monocular camera. Then a sequential pose moves with multiple payload weights on the manipulator end has been performed as a performance measurement of repair jobs using a vision-based position tracking algorithm. The measurement results demonstrate that RIRS can maintain accurate and consistent performance in both defect position inspection and repair moves with diverse payloads. For inspection the positional error was only 0.27% while for repair moves the end-effector can reach the same position within 1mm. This research establishes a foundation for system command & control development and supporting more practical railway jobs deployment towards full autonomy for RIRS in the future.

No abstract

No abstract

High value systems are determined by a wide structure, where operations are considered to be one structural component. Nowadays "downtime" as a major impact in the operation costs of any system. To avoid or minimize "down-time" it is essential to match the appropriate maintenance to each failure. Therefore, it is relevant to determine the cost drivers of integrated maintenance in any system, in order to minimize the overall cost. It is common to use Value Driven Maintenance (VDM) to capture the cost drivers in maintenance. VDM is a methodology which relies in four distinct areas: Asset Utilization; Resource Allocation; Control Cost and Health and Safety and Environment. Within each category it is possible to allocate different cost drivers, building a framework for each system studied. The aim of this paper is to categorize the cost drivers of rail infrastructure networks, associating them with the maintenance preformed for each case. Furthermore, analysis of which part of the track falls under each VDM category as well as the general failure causes and effects will be included in the framework presented. Finally relating the maintenance type for each effect will provide the necessary inputs towards a cost model structure. The benefit of achieving a successful model will be the optimization of the cost in integrated maintenance of the rail infrastructure.

No abstract