Background: The quality and duration of analgesia is improved when a local anesthetic is combined with alpha 2 adrenergic agonist. Though, the effects of clonidine on local anesthetics have been extensively studied, there are limited studies demonstrating the effects of epidural dexmedetomidine on local anesthetics. The aim of our study is to compare the effect of clonidine and dexmedetomidine when used as an adjuvant to ropivacaine for post operative analgesia after lower limb surgeries. Materials and Methods: Primary anesthetic technique in all the patients was spinal anesthesia. However femoral nerve block was placed at the completion of surgery by randomizing patients in two groups:Group C (20ml 0.25% Ropivacaine +1mcg/kg Clonidine) and Group D (20ml 0.25% Ropivacine +1mcg/kg Dexmedetomidine ) both containing 35 patients Onset of analgesia , duration of analgesia(It is time interval between administration of FNB & demand of rst resue analgesic ,total no of Rescue analgesics required in 24 hrs and quality of analgesia ,hemodynamic stability, post operative sedation scoring ,failure rate of technique and complications were recorded. Results: We found signicant difference in onset(9.41 ±0.73 mins) and duration(7.69±0.69 mins) of analgesia in group C as compared to onset(3.08 ±0.61 mins) and duration(11.16±0.58 mins) of analgesia in group D. No signicant complications were seen in either of the group.Conclusion: Dexmedetomidine at doses of 1 μg/kg is an effective adjuvant to ropivacaine for post operative analgesia after lower limb procedures .
Aims and Objective: Aim of the present study was to compare the clinical efficacy of 0.5% hyperbaric solutions of ropivacaine versus bupivacaine in terms of characteristics of spinal blockade, haemodynamic stability, recovery profile and side effects. Material and Method:The study enrolling 100 patients (age 20-60 years) of either sex, ASA grade I & II were randomly allocated in two groups. Group R received 3 ml of 0.5% hyperbaric ropivacaine with glucose 8.33% and Group B received 3 ml of 0.5% hyperbaric bupivacaine with glucose 8%. After induction, we studied the various parameters of subarachnoid block, hemodynamic variables, recovery and side effects. Result: Hyperbaric ropivacaine had late onset of sensory blockade, equal time to reach maximum dermatome level, early regression and shorter total duration of sensory blockade as compared to bupivacaine. Ropivacaine shows late onset of motor blockade, less degree and total duration of motor blockade as compared to bupivacaine. Ropivacaine was more hemodynamically stable as compared to bupivacaine. Both the sensory and motor blocks were subject to a more rapid recovery with ropivacaine compared with bupivacaine. Hyperbaric ropivacaine was not associated with any side effects intra and postoperatively. Conclusion: 3 ml of hyperbaric solution of ropivacaine 0.5% with glucose 8.33% can produce predictable and reliable spinal anaesthesia for a wide range of surgical procedure.
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