The reaction of diorganotin dichloride with benzoyl acetone and O-alkyl trithiophosphate have been carried out in 1:1:1 molar ratio in refluxing benzene. The newly synthesized complexes R 2 Sn[PhCOCHCOMe][SSH(S)POR'] are found to be non volatile, light yellow coloured crystalline solids, monomeric in nature and highly sensitive towards atmospheric moisture. These complexes were characterized by elemental analysis (S,Sn), molecular weight measurements, IR and NMR ('H/'P.'^Sn) spectral data. On the basis of spectral studies, the bidentate nature of benzoyl acetonate and O-alkyl trithiophosphate moieties and the hexacoordinated nature of tin atom was established. All these newly synthesized compounds were tested for their antibacterial activity against gram positive and gram negative bacteria. All compounds showed good activity against bacteria. Synthesis and Properties of Mixed Ligand Complexes Of Diorganotin(IV): Part(VI): general, ß-diketonates show facile reactivity towards metal alkoxide, in which alkoxy group of metal alkoxide is easily replaced by the enolate form of ß-diketonate. Diisopropyltin(lV) trithiophosphate and their adducts with nitrogen donar bases have also been reported in the literature /12/. O-alkyl, O-cycloalkyl and O-aryl trithiophosphato derivatives of trimethyl-and tributyl tin(lV) chloride have also been synthesized and characterized by various spectral studies /13/.The mixed derivatives of diorganotin (IV) with ß-diketonates and alkyl trithiophosphates have not been studied so far. In view of the above, it was considered of interest to synthesize and study the chemical bonding modes in these new derivatives. These newly synthesized derivatives showed higher anti-bacterial activity at 500 μg/mL concentration against gram-negative and gram-positive bacteria.In the present communication, we report the synthesis and spectroscopic properties of mixed ligand complexes of the type R 2 Sn[SSH(S)POR'][C 6 H5COCHCOCH 3 ].
MATERIALS AND METHODSOwing to the hygroscopic nature of the mixed ligand complexes, stringent precautions were taken to exclude moisture. Sulphur and tin were estimated gravimetrically as barium sulphate (Messenger's method /14/) and tin oxide, respectively. Α Knauer vapour pressure osmometer in chloroform was used for molecular weight determination. FTIR spectra were recorded on a Shimadzu 8201 PC spectrophotometer in the range of 4000-200 cm" 1 using Csl cells. 'H NMR spectra (in CDC1 3 ) and 31 P and 119 Sn NMR spectra (in benzene)were recorded on Bruker DRX-300 spectrophotometer using TMS (for 'H), H 3 P0 4 (for 31 P) and Me 4 Sn (for 119 Sn) as external references.
Synthesis of Me 2 Sn[PhCOCHCOMe][SSH(S)POPh]A mixture of dimethyltin dichloride (1.08 g; 4.91 mmole), benzoyl acetone (0.79 g; 4.88 mmole), Ophenyl trithiophosphate (1.46 g; 4.90 mmole) are taken in dry benzene (-35 mL). The reaction mixture is then refluxed for about 10 hours, Precipitate of KCl formed during the course of the reaction, is removed by Alteration in anhydrous condition and excess of solvent (benzene...
ABSTRACTp-Nitrophenyl and p-nitrobenzoyl derivatives of O,O'-alkylene dithiophosphate, OGOP(S)SC 6 H 4 NO 2 and OGOP(S)SCOC 6 H 4 NO 2 (Where G = -CMe 2 CMe 2 -, -CH 2 CMe 2 CH 2 -, -CMe 2 CH 2 CHMe-, -CH 2 CH 2 CHMe-) have been synthesized by the reactions of p-bromo nitrobenzene / p-nitrobenzoyl chloride with ammonium salt of alkylene dithiophosphoric acids. These derivatives are yellow and red coloured solids, respectively and are soluble in common organic solvents. These are characterized by elemental analysis, IR and NMR ( 1 H and 31 P) spectral studies. In contrast to the bi-dentate chelating behaviour of the ligand in the metal and organometal derivatives of alkylene dithiophosphates, the behaviour of dithiophosphato moiety in these derivatives is found to be mono-dentate in nature.
A series of some new mixed ligand complexes have been synthesized with an objective for evaluation as antimicrobials. Reactions of diorganotin(IV) dichloride with dibenzoyl methane and O‐alkyl trithiophosphates in a 1:1:1 molar ratio in refluxing benzene yield products of the type [PhCOCHCOPh]R2Sn‐[SSH(S)POR'] [where R = Me, Bu, Ph; R' = Me, Et, Pri, Bui, Ph]. The newly synthesized complexes are light yellow colored crystalline solids, non‐volatile, soluble in common organic solvents, monomeric in nature and highly sensitive towards atmospheric moisture. These complexes are characterized by elemental analysis, IR and multinuclear NMR (1H, 31P and 119Sn) spectral studies. Spectral studies of these complexes indicate that dibenzoyl methane and O‐alkyl trithiophosphate moieties are bidentate and the central tin atom is hexacoordinated in nature. A few of these compounds were tested for their antibacterial activity using standard drugs.
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