Obstructive sleep apnea is a chronic, sleep-related breathing disorder, which is an independent risk factor for cardiovascular disease. The renin-angiotensin-aldosterone system regulates salt and water homeostasis, blood pressure, and cardiovascular remodelling. Elevated aldosterone levels are associated with excess morbidity and mortality.We aimed to analyse the influence and implications of renin-angiotensin-aldosterone system derangement in individuals with and without obstructive sleep apnea. We pooled data from 20 relevant studies involving 2828 participants (1554 with obstructive sleep apnea, 1274 without obstructive sleep apnea). The study outcomes were the levels of renin-angiotensin-aldosterone system hormones, blood pressure and heart rate. Patients with obstructive sleep apnea had higher levels of plasma renin activity (pooled wmd+ 0.25 [95% confidence interval 0.04-0.46], p = 0.0219), plasma aldosterone (pooled wmd+ 30.79 [95% confidence interval 1.05-60.53], p = 0.0424), angiotensin II (pooled wmd+ 5.19 [95% confidence interval 3.11-7.27], p < 0.001), systolic (pooled wmd+ 5.87 [95% confidence interval 1.42-10.32], p = 0.0098) and diastolic (pooled wmd+ 3.40 [95% confidence interval 0.86-5.94], p = 0.0086) blood pressure, and heart rate (pooled wmd+ 3.83 [95% confidence interval 1.57-6.01], p = 0.0009) compared with those without obstructive sleep apnea. The elevation remained significant (except for renin levels) when studies involving patients with resistant hypertension were removed. Sub-group analysis demonstrated that levels of angiotensin II were significantly higher only among the Asian population with obstructive sleep apnea compared with those without obstructive sleep apnea. Body mass index accounted for less than 10% of

A large number of experimental investigations have been carried out on plasma focus devices especially at low energy level of several kJ or over 100 kJ. There are few machines operating in the middle energy range of 10-50 kJ, where the neutron yield typically in the order of 10 8 -10 9 per shot. This paper reviews the optimisation process of two different plasma focus devices (12 kJ) by applying the Lee model code. The neutron yield (Y n ) versus pressure (P) curve for several configurations of the two plasma focus provided insight of geometrical optimisation. Measured discharge current is fitted as the first step of modelling to correctly simulate the plasma dynamics. Subsequently the code is used to simulate the neutron yield of the two plasma focus devices based on beam target mechanism. Good agreement between the computed results of neutron yield versus pressure and the measured yield versus pressure is found up to the pressure where highest neutron yield is obtained. Computed highest neutron yield for most of the configuration typically differ by a factor\2.

In published literature, there has been scant data on radial trajectory of the plasma focus and no comparison of computed with measured radial trajectory. This paper provides the first such comparative study. We compute the trajectories of the inward-moving radial shock and magnetic piston of UMDPF1 plasma focus and compare these with measured data taken from a streak photograph. The comparison shows agreement with the measured radial trajectory in terms of average speeds and general shape of trajectory. This paper also presents the measured trajectory of the radially compressing piston in another machine, the UMDPF0 plasma focus, confirming that the computed radial trajectory also shows similar general agreement. Features of divergence between the computed and measured trajectories, towards the end of the radial compression, are discussed. From the measured radial trajectories, an inference is made that the neutron yield mechanism could not be thermonuclear. A second inference is made regarding the speeds of axial post-pinch shocks, which are recently considered as a useful tool for damage testing of fusion-related wall materials.

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