Described herein is an efficient asymmetric synthesis of the potent antiarrhthymia agent The route is convergent and is highlighted by two stereoselective reactions. A rutheniumcatalyzed, enantioselective hydrogenation of an enamide was developed for the preparation of the key amine intermediate. Oxazaborolidine-mediated ketone reduction was utilized to establish the alcohol stereochemistry. Optimization of this chemistry led to an IPA modified reduction method which provides enhanced stereoselectivity.
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