Long-acting somatostatin analogs are often used for treating acromegaly, either as adjuvant to surgery or radiotherapy or, more recently, as a primary therapeutic option. These drugs seem to be reasonably safe, but new adverse effects not yet described may occur during the use of the relatively new longacting formulations. In this case report, we describe a severe cutaneous reaction (erythema multiforme) in a patient treated with long-acting release (LAR) octreotide, and also discuss the need of previous "testing" with short subcutaneous preparation of octreotide. RESUMOEritema Multiforme Associado ao Octreotide-LAR em uma Paciente Acromegálica: Relato de Caso. Análogos da somatostatina de longa duração são freqüentemente usados no tratamento da acromegalia, como adjuvante à cirurgia ou à radioterapia ou, mais recentemente, como opção terapêutica primária. Essas drogas parecem ser razoavelmente seguras, mas podem ocorrer feitos colaterais ainda não descritos com o uso das relativamente novas formulações de ação prolongada. Neste relato de caso, descrevemos uma reação cutânea grave (eritema multiforme) em uma paciente tratada com octreotide de liberação prolongada (LAR) e discutimos a necessidade de submeter os pacientes previamente a um "teste" com a formulação subcutânea do octreotide de ação rápida. Descritores: Octreotide/efeitos adversos; Eritema multiforme; Acromegalia; Somatostatina/análogos e derivados.
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