This article details the preparation and spectroscopic characterization of a focused library of new 18-electron ruthenocenyl complexes incorporating pentasubstituted Cp ester [C 5 (CO 2 R) 5 ] -(for R = Me, Et, n-Pr, n-Bu, 2-Pr, 3-Pent, phenyl, and n-thiopropyl), carboxylic acid [C 5 (CO 2 H) 5 ] -, and carboxylate ligands [C 5 (CO 2 H) 4 (CO 2 )] 2-. Each complex has been characterized using Fourier transform IR and NMR spectroscopy and electrospray mass spectrometry, with single-crystal X-ray structural determinations reported for four complexes: [Ru(η 5 -C 5 H 4 (C 5 (CO 2 CH 3 ) 5 )(η 5 -C 5 (CO 2 -CH , -C 5 H 5 )(η 5 -C 5 (CO 2 C 6 H 5 ) 5 )]. Complexes were also evaluated for in vitro cytotoxic activity against a diverse panel of tumorigenic cell lines and a normal human cell line.

This article outlines the synthesis and characterization of a structurally diverse range of mono-and 1,1 0 -disubstituted ruthenocenyl complexes. Compounds were prepared through organic manipulation of ruthenocenefluorocarbonyl and carboxylic acid functional groups and via the Friedel-Crafts acylation of ruthenocene. A dimetalated acid anhydride of the formula [Ru(η 5 -C 5 H 5 )(η 5 -C 5 H 4 -CO)] 2 O was also prepared, and the X-ray structure of this molecule is reported. Complexes were evaluated for their antiproliferative properties against a range of tumorigenic cell lines and a control human fibroblast, with results indicating these organoruthenium metallocenes to possess moderate to weak cytotoxicity toward cancerous cells.

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