The iron-catalysed reduction of olefins has been achieved using a simple iron salt and sodium triethylborohydride. A wide range of monoand trans-1,2-disubstituted alkenes have been reduced (91-100%) using 25 mol% iron(II) triflate, 1 mol% N-methyl-2-pyrrolidinone and 4 equivalents of sodium triethylborohydride. The reduction of alkynes to alkanes is also reported (up to 84%). Significantly, the reduction of trisubstituted alkenes has also been achieved (60-86%). Scheme 3. Recycling of catalyst solution in the reduction of trans-stilbene (A) and mechanistic investigations (B)-(D).
<p>Supplementary data gathers supplementary table 1 and supplementary figure 1. Supplementary table 1: inhibition profile relationship for Axl related to sequence identity. Supplementary figure 1: structure of the described Axl's inhibitors</p>
Iron-Catalyzed Reduction of Olefins Using a Borohydride Reagent. -Excellent yields are observed for the aliphatic and aromatic terminal alkenes. The reaction proceeds more effectively when (E)-internal alkenes are applied [cf. (IV)]. Attempts to carry out the asymmetric version of the reaction fail as nearly racemic products are obtained. In the reduction of alkynes the amount of NaBHEt3 is crucial. -(CARTER, T. S.; GUIET, L.; FRANK, D. J.; WEST, J.; THOMAS*, S. P.; Adv. Synth. Catal. 355 (2013) 5, 880-884, http://dx.
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