Primary laryngeal amyloidosis (PLA) and granulomatosis with polyangiitis (GPA) can present rarely with the isolated symptom of dyspnea and/or dysphonia, affecting exclusively the larynx.Granulomatosis with polyangiitis is one of the anti-neutrophil cytoplasmatic antibodies (ANCA) associated vasculitis. It may be limited to the airways including may be exclusively laryngeal. This localized form of GPA has a diffi cult diagnosis because the biopsy rarely does the diagnosis and the ANCA tests are frequently negative.In the aim of emphasizing the importance of this rare entity as a differential diagnosis of localized granulomatosis with polyangiitis, we report two cases of PLA treated in our Service.
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