SARS-CoV e MERS-CoV, vírus da família Coronaviridae, já foram responsáveis por epidemias passadas, no entanto apesar de similares, a magnitude da pandemia ocasionada pelo SARS-CoV-2 está além do já observado. Mesmo que pertençam à mesma família e causem sintomas parecidos, a COVID-19, doença ocasionada pelo SARS-CoV-2, possui diversas particularidades que não são observadas nas outras síndromes respiratórias. Apesar de possui a menor taxa de letalidade, os sintomas desenvolvidos pela COVID-19 podem se tornar persistentes e afetar a qualidade de vida, deixando sequelas significativas. Além disso, sintomas incomuns encontrados em pacientes vítimas da doença causada pelo SARS-CoV-2 ainda estão em constante observação. A grande capacidade de transmissão e a gravidade da doença são fatores que impulsionaram a ciência a trabalhar, em tempo recorde, visando um mesmo objetivo: entender o vírus para controlar a sua disseminação.
Rotaviruses belonging to species A (RVA) remain among the most common causes of severe gastroenteritis in children aged <5 years, leading to substantial morbidity and mortality worldwide. Genome reassortment events between two human strains or human and animal strains represent one of the mechanisms which appear to generate the broad genetic variability of circulating. According to a nucleotide, sequence-based classification system, RVA strains are currently classified into three genotype constellations including Wa-like (genogroup I), DS-1-like (genogroup II), and AU-like (genogroup III). The present study reports the detection of an unusual RVA G4P[6] strain (coded as strain HSE005), which might have originated from a natural reassortment event between human and animal RVA strains. Molecular characterization of this isolate showed that it belonged to genogroup II, genotype G4P[6]. In addition, two genes (VP3 and NSP4) of this strain denoted evidence of reassortment events involving strains of distinct zoonotic evolutionary origins. Therefore, we propose that a new G4P[6] strain was identified, highlighting a possible first zoonotic transmission including a reassortment event that involved the VP3 gene.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.