Zinc is a potent reversible inlubitor of the pH-dependent anion-conductmg channel m the mitochondrial inner membrane, 50% inhibition was produced by 1.5 PM added Zn" at which point free Zn" was 5 10~8 M. Inhibition by Zn" IS rapid but can be prevented or rapidly reversed by excess EDTA. Concentrations of Zn" higher than 4 PM caused reversal of inhibition to a variable extent depending on the anion. Under these conditions Zn*' did not inhibit ribose entry, the phosphate transporter, or the pH-Insensitive component of the NO,-uniport.
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