Herein, we report a simple method
for functionalized enals involving
enal-transfer reaction of water-soluble N-methoxypyridazinium
salts. This open-flask reaction proceeds under mild aqueous basic
conditions through [2,3]-sigmatropic rearrangement of propargyl/allyl
sulfur-ylides derived from in situ-generated Rh-(E)-enalcarbene. Various synthetically challenging allene- and allyl-functionalized
(E)-enals with a γ-C(sp3) quaternary
center were obtained in good to high yields. InCl3-catalyzed
cascade cyclization of allenyl-enal and aniline gave a valuable pyrrolo[1,2-a]quinoline motif.
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