Large intravenous doses of a pyrogen to In the dog, the fall in urine osmolality (and the dog results in a diuresis which is associ-refractoriness to ADH) has been related to a ated with an increased Solute excretion, a fall *This work was supported by funds from Nain urine osmolality, and is uniformly associtional Research Council of Canada and Quebec ated with a rise in total renal blood flow( 1,2). Heart Foundation.
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