An extensive study of the relationship between the structure of a number of bis-epoxides and their activity against the Walker carcinosarcoma 256 in the rat has been reported by Ross.1 This study revealed a distinct correlation of the chemical reactivity of the epoxide function towards anions and the observed biological effectiveness. Diepoxybutane was found to be one of the most active compounds, while a few primary aromatic amine bisepoxides, e.g. N,N-bis(2,3-epoxypropyl)anisidine, were reported to possess low activity against the tumour system employed.

Rotator cuff pathology is a commonly encountered clinical and radiologic entity that can manifest as tendinopathy or tearing. Magnetic resonance imaging (MRI) and ultrasonography offer similar sensitivity and specificity for the evaluation of the native rotator cuff, and the chosen modality may vary, depending on local practice and accessibility. MR arthrography is frequently used in the postoperative setting as a problem-solving tool. Key findings to include in the preoperative MRI report include the size and location of the tear, thickness of the tendon involved (partial versus full thickness), and overall tendon quality. The report should also address features associated with poor surgical outcomes, such as fatty atrophy, a decreased acromiohumeral interval, and evidence of rotator cuff arthropathy. Musculoskeletal radiologists should be familiar with the various surgical techniques and expected postoperative imaging appearance of rotator cuff repairs. Imaging also plays a role in identifying recurrent tearing, graft failure, hardware loosening, infection, and other complications.