The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined. This is the first complete sequence analysis of an entire chromosome from any organism. The 315-kilobase sequence reveals 182 open reading frames for proteins longer than 100 amino acids, of which 37 correspond to known genes and 29 more show some similarity to sequences in databases. Of 55 new open reading frames analysed by gene disruption, three are essential genes; of 42 non-essential genes that were tested, 14 show some discernible effect on phenotype and the remaining 28 have no overt function.

Structural health monitoring using Lamb waves is based on guided waves introduced to a structure at one point and sensed at a different location. Actuation and sensing can be accomplished using various types of transducer. The paper demonstrates a non-contact method for low-frequency Lamb wave sensing. The technique utilizes a laser Doppler velocimeter. Lamb wave responses are enhanced using data smoothing and filtering procedures. The results are validated using classical piezoceramic-based sensing and numerical simulations. The study shows the potential of laser vibrometry for Lamb wave sensing.

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