We report two asymmetric ligands for the generation of structural and functional dinuclear metal complexes as phosphoesterase mimics. Two zinc(II) complexes, [Zn 2 (CH 3 L4)(CH 3 CO 2 ) 2 ] + (CH 3 HL4 = 2-(((2-methoxyethyl)( pyridin-2-ylmethyl)amino)methyl)-4-methyl-6-((( pyridin-2-ylmethyl)amino)methyl)-phenol) and [Zn 2 (CH 3 L5)(CH 3 CO 2 ) 2 ] + (CH 3 HL5 = 2-(((2-methoxyethyl)( pyridine-2-ylmethyl)amino)-methyl)-4-methyl-6-((( pyridin-2-ylmethyl)(4-vinylbenzyl)amino)methyl)phenol) were synthesized and characterized by X-ray crystallography. The structures showed that the ligands enforce a mixed 6,5-coordinate environment in the solid state. 1 H-, 13 C-and 31 P-NMR, mass spectrometry and infrared spectroscopy were used to further characterize the compounds in the solid state and in solution. The zinc (II) complexes hydrolyzed the organophosphate substrate bis-(2,4-dinitrophenol)phosphate (BDNPP), the nucleophile proposed to be a terminal water molecule ( pK a 7.2). The ligand CH 3 HL4 was immobilised on Merrifield resin and its zinc(II) complex generated. Infrared spectroscopy, microanalysis and XPS measurements confirmed successful immobilisation, with a catalyst loading of ∼1.45 mmol g −1 resin. The resin bound complex was active towards BDNPP and displayed similar pH dependence to the complex in solution.
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