PurposeDevelopment of a method to assess the drug/polymer miscibility and stability of solid dispersions using a melt-based mixing method.MethodsAmorphous fractured films are prepared and characterized with Raman Microscopy in combination with Atomic Force Microscopy to discriminate between homogenously and heterogeneously mixed drug/polymer combinations. The homogenous combinations are analyzed further for physical stability under stress conditions, such as increased humidity or temperature.ResultsCombinations that have the potential to form a molecular disperse mixture are identified. Their potential to phase separate is determined through imaging at molecular length scales, which results in short observation time. De-mixing is quantified by phase separation analysis, and the drug/polymer combinations are ranked to identify the most stable combinations.ConclusionsThe presented results demonstrate that drug/polymer miscibility and stability of solid dispersions, with many mechanistic details, can be analyzed with Atomic Force Microscopy. The assay allows to identify well-miscible and stable combinations within hours or a few days.Electronic Supplementary MaterialThe online version of this article (doi:10.1007/s11095-010-0306-4) contains supplementary material, which is available to authorized users.
The photon density wave (PDW) spectroscopy is established in the fields of biochemistry and food chemistry as an online analytical method for the determination of mean particle sizes.
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