Self-expanding, metal biliary stents have recently been used in malignant obstructive jaundice as their large diameter reduces the likelihood of occlusion by biliary sludge and bacterial biofilm. However, there is a significant rate of late obstruction by tumour overgrowth and infiltration through the wire mesh. Our case of stent erosion through the duodenal wall, resulting in massive haemorrhage, is a hitherto unreported serious complication of the Wallstent (Schneider). Its occurrence may be suggested by continuous upper abdominal pain, gastrointestinal bleeding or late expansion of the stent.
SUMMARY
Sodium taurocholate, 0·125 to 2·0 mg./ml. bath fluid, reversibly inhibited isometric contractions of rat's ileum in response to Ach, 10−8 to 10−4. The degree of inhibition depended on the relative proportions of the two substances. In depolarizing solution, K2SO4‐Ringer, taurocholate inhibited the Ach response of rat's ileum, rat's uterus and circular muscle of toad's stomach. In calcium‐free K2SO4‐Ringer taurocholate inhibited calcium contractures in these three preparations. It is suggested that taurocholate may interfere with a mechanism coupling excitation to contraction and involving calcium.
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