Childhood cancer survivors are at increased risk for treatment-related late effects; data are lacking on how coronavirus disease 2019 (COVID-19) infection impacts this cohort. We assessed COVID-19-related symptoms, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG seroprevalence, and rate of COVID-19-related hospitalization among 321 asymptomatic survivors of childhood cancer or transplantation seen for routine long-term follow-up between May and September 2020 in a New York City tertiary cancer center. While 10.9% (n = 35) reported possible COVID-19-related symptoms, 7.8% (n = 20) of those tested had positive SARS-CoV-2 IgG, and one patient (0.3%) required COVID-19-related hospitalization. This report suggests that childhood cancer survivors appear to be at relatively low risk for COVID-19 complications. K E Y W O R D S childhood cancer, COVID-19, SARS-CoV-2, survivors This retrospective review included all consecutive survivors seen in Memorial Sloan Kettering (MSK)'s Pediatric LTFU Clinic between May 5 and September 10, 2020, which provides risk-based care to survivors of childhood cancer and HCT diagnosed at age ≤18 who are ≥1-year off-therapy at program entry.

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