Sexually active 12- to 16-year-olds should be tested for chlamydia, and establishing their sexual history is crucial. Amending the current Australian guidelines to annual testing of any sexually active person under the age of 30 years should be considered.
infection in 'humanized' mouse models provides an unprecedented ability to study this exquisitely host-adapted pathogen in vivo, facilitating efforts to define the contribution of virulence factors to infection and immunopathogenesis, and providing a tractable model in which to test vaccine candidates. Finally, the re-establishment of human male volunteer urethral challenge models provides a clear path for the definitive validation of high priority vaccine formulations. The material nature of these advances has energized the community to coordinate efforts in the common goal of developing a vaccine to defeat this relentless pathogen.
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