Abstract:infection in 'humanized' mouse models provides an unprecedented ability to study this exquisitely host-adapted pathogen in vivo, facilitating efforts to define the contribution of virulence factors to infection and immunopathogenesis, and providing a tractable model in which to test vaccine candidates. Finally, the re-establishment of human male volunteer urethral challenge models provides a clear path for the definitive validation of high priority vaccine formulations. The material nature of these advances ha… Show more
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