Highlights d A proteomic screen found 200 neuronal cell-surface proteinprotein interactions d 89 of these interactions appeared to be previously unpublished d The five interacting IgLON proteins were identified and further characterized d The structures of NTRI, IgLON5, and the NEGR1/IgLON5 complex are presented
The expression of the autism-related mutant R451C neuroligin3 activates the three branches of the unfolded protein response in neuronal-like PC12 cells and leads to up-regulation of the response target genes BiP and CHOP.
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