Background
High-risk mucosal human papillomavirus (HR-HPV) seems to play a role in cutaneous squamous cell carcinoma (cSCC), particularly in nail tumours, where genitodigital transmission has been suggested. The role of HR-HPV in nonungual cSCC of the finger needs to be clarified.
Aim
To evaluate the prevalence, clinicopathological characteristics, surrogates and outcomes of HR-HPV in cSCC of the finger.
Methods
This was an observational bicentric study including patients with an excised in situ or invasive cSCC located on the finger. Differences in HR-HPV and non-HR-HPV tumours were evaluated.
Results
Forty-five patients (45 tumours) were included. HR-HPV was detected in 33% of cases (22% HPV type 16). The mean age was lower in patients with HR-HPV than in those with non-HR-HPV (62·4 vs. 81·1 years, P = 0·001). HR-HPV tumours were smaller (10 mm vs. 15 mm, P = 0·07) and more frequently intraepidermal (60% vs. 20%, P = 0·004). The absence of elastosis (P = 0·030) and inflammation (P = 0·026) and the presence of basaloid morphology (P = 0·003) were surrogates of HR-HPV detection. Mean p16 positivity was 61% in HR-HPV and 36% in non-HR-HPV tumours (P = 0·061). Recurrence after surgery was more common in HR-HPV tumours (58% vs. 34%), although this was not statistically significant. HR-HPV was detected in 27% of the nonungual tumours.
Conclusion
HR-HPV-associated cSCC of the finger appears in younger patients, is smaller and is less infiltrative than non-HR-HPV tumours. The presence of a basaloid morphology and the absence of elastosis and inflammation could be used as markers for HR-HPV detection. The high prevalence of HR-HPV in nonungual cSCC suggests its aetiopathogenic role in these tumours.
Background: Skin cancer is a serious health problem in our society, and UV radiation is the most significant agent in its development. Photoprotection and awareness of the risks of developing skin cancer are the basic pillars in its prevention. As future healthcare professionals, medical students’ knowledge of these questions is likely to influence the effectiveness with which they can promote appropriate behavior regarding sun exposure among their patients. Our objective was to assess the knowledge and awareness of photoprotection among medical students and their behavior regarding sun exposure.Methods: A Google questionnaire comprising 54 questions about the risks of skin cancer and photoprotective habits was developed. 228 participants were recruited to the study, of whom sixth-year and fourth-year students were the most and least strongly represented groups, respectively. Statistical analysis was performed using IBM SPSS Statistics 26.Results: Significantly more fifth- and sixth-year students had knowledge of the meaning of the sun protection factor (SPF) than those in pre-clinical years (P=0.006), and more of them were aware of the risks of developing skin cancer (P=0.039). A higher percentage of female than male students took FPS into account when buying sunscreen (P=0.023), and male students are more likely to be reluctant to apply sunscreen than female students (P=0.022). A higher proportion of women than men in the study used sunscreen for outdoor activities (P=0.015).Conclusions: Prevention of sun overexposure is a public health priority, and medical students will be in charge of informing the general population in the future. Most students who are currently studying medicine have some knowledge of skin cancer prevention, although there are significant differences between sexes and year of study. However, their behavior indicates that their knowledge does not consistently translate from theory into practice.
Performance of Salamanca's refinement of the AJCC8 for T3 cutaneous squamous cell carcinoma (CSCC), versus the Brigham and Women's Hospital's alternative staging system and the Tübingen's alternative staging system for high-risk CSCC
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