Peptide/MHC complexes recognized by alloreactive T lymphocytes (TLs) have been identified, but their contribution to in vivo allo-rejection is not known. We previously characterized the peptide pBM1, highly represented among endogenous H-2K ing that it is recruited upon immunization for its optimal TCR-peptide/MHC fit. Thus, a CDR3b motif generated by a process akin to ''convergent recombination'' accounts for a sizable fraction of the alloreactive anti-K b TCR repertoire.
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