Research suggests that culture influences how people perceive the world, which extends to memory specificity, or how much perceptual detail is remembered. The present study investigated cross-cultural differences (Americans vs. East Asians) at the time of encoding in the neural correlates of specific vs. general memory formation. Participants encoded photos of everyday items in the scanner and 48 hours later completed a surprise recognition test. The recognition test consisted of same (i.e., previously seen in scanner), similar (i.e., same name, different features), or new photos (i.e., items not previously seen in scanner). For Americans compared to East Asians, we predicted greater activation in the hippocampus and right fusiform for specific memory at recognition, as these regions were implicated previously in encoding perceptual details. Results revealed that East Asians activated the left fusiform and left hippocampus more than Americans for specific vs. general memory. Follow-up analyses ruled out alternative explanations of retrieval difficulty and familiarity for this pattern of cross-cultural differences at encoding. Results overall suggest that culture should be considered as another individual difference that affects memory specificity and modulates neural regions underlying these processes.

Age-related increases in reliance on gist-based processes can cause increased false recognition. Understanding the neural basis for this increase helps to elucidate a mechanism underlying this vulnerability in memory. We assessed age differences in gist-based false memory by increasing image set size at encoding, thereby increasing the rate of false alarms. False alarms during a recognition test elicited increased hippocampal activity for older adults as compared to younger adults for the small set sizes, whereas the age groups had similar hippocampal activation for items associated with larger set sizes. Interestingly, younger adults had stronger connectivity between the hippocampus and posterior temporal regions relative to older adults during false alarms for items associated with large versus small set sizes. With increased gist, younger adults might rely more on additional processes (e.g., semantic associations) during recognition than older adults. Parametric modulation revealed that younger adults had increased anterior cingulate activity versus older adults with decreasing set size, perhaps indicating difficulty utilizing monitoring processes in error-prone situations.

Prior cross-cultural research has reported cultural variations in memory. One study revealed that Americans remembered images with more perceptual detail than East Asians (Millar et al. in Cult Brain 1(2–4):138–157, 2013). However, in a later study, this expected pattern was not replicated, possibly due to differences in encoding instructions (Paige et al. in Cortex 91:250–261, 2017). The present study sought to examine when cultural variation in memory-related decisions occur and the role of instructions. American and East Asian participants viewed images of objects while making a Purchase decision or an Approach decision and later completed a surprise recognition test. Results revealed Americans had higher hit rates for specific memory, regardless of instruction type, and a less stringent response criterion relative to East Asians. Additionally, a pattern emerged where the Approach decision enhanced hit rates for specific memory relative to the Purchase decision only when administered first; this pattern did not differ across cultures. Results suggest encoding instructions do not magnify cross-cultural differences in memory. Ultimately, cross-cultural differences in response bias, rather than memory sensitivity per se, may account for findings of cultural differences in memory specificity.

Research has shown that remembering emotional information can occur at the expense of surrounding neutral background information; this emotional memory trade-off occurs similarly in both younger and older adults. We investigated how levels of cortisol, a hormone that acts on the central nervous system, impact emotional memory with age. Younger and older adult participants incidentally encoded emotional (positive, negative, or neutral) items placed on neutral backgrounds and later completed recognition tests for both the items and the backgrounds. Cortisol was measured at multiple time points to assess basal cortisol. Results are reported for prelearning levels, as findings were comparable across time points. Results revealed that higher levels of cortisol predicted a lower memory trade-off effect for older adults compared to younger adults and that this age difference in the role of cortisol tended to be strongest for memory for negative items (rather than for backgrounds or neutral items). No such interaction emerged for the positive trade-off effect. These results suggest that cortisol levels play a different role in supporting emotional memory across the life span, with lower levels of cortisol potentially more adaptive for memory for negative emotional information and higher levels indicating potential impairment with age.

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