Keywords:Idiopathic intracranial hypertension, Cerebrospinal fluid, Phase contrast-cine magnetic resonance imaging, dural venous stenosis, papilledema Running title: MR fluid analysis in IIH Abbreviations: AaCD=artero-aqueduct CSF delay; AcCD= artero-cervical CSF delay; aCSF=CSF through the AoS; AoS=aqueduct of Sylvius; AVD=arterovenous delay; CC= cardiac cycle; cCSF=CSF in the cervical subarachnoid space; CSF=cerebrospinal fluid; CVO=cerebral venous outflow; ICA=internal carotid artery; ICP = intracranial pressure; IIH = idiopathic intracranial hypertension; IJV=internal jugular vein; tA=total cerebral arterial inflow; tIJV=total outflow from internal jugular veins; LP=lumbar puncture; RFNL = retinal fiber nerve layer; PCC-MR=phase contrast cine magnetic resonance; SAS=subarachnoid space; TS=transverse sinus; VA= vertebral artery peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/245894 doi: bioRxiv preprint first posted online Jan. 19, 2018; Analyses were run before lumbar puncture (LP) (A), after LP (B), after medical therapy (C) and after venous stent placements deployed at two separate times (D and E). AVD and tIJV/tA improved only after CSF removal and after stent placements. CSF velocity amplitude remained elevated. Arterial flow profile showed a dramatic reduction after LP with improvement in mean venous flow. This report is the first to demonstrate interactive changes in intracranial fluid dynamics that occur before and after different therapeutic interventions in IIH. We discuss how increased intracranial venous blood could be "tumoral" in IIH and facilitating its outflow could be therapeutic.peer-reviewed)

The data provide valuable information regarding changes in different fluid compartments suggesting a profound redistribution of pressures along fluid compartments after different treatments. We discuss how increased intracranial venous blood could be "tumoral" in IIH and facilitating its outflow could be therapeutic.

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