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Trichodertna longibmchinturn Rifai aggr. is a fungus reported to be antagonistic to the fungus Mycenn citricolor, the causative agent of the American leaf spot disease of coffee. We have investigated the metabolites produced when ir: kot~gibrnchint~~rn is grown in liquid culture and have isolated several new compounds. The structures of trichodermolide (2) and sorbiquinol(3) were determined by a combination of spectroscopic techniques, including I H and I3c NMR, IR, UV, CD, ORD, and mass spectrometry, and by preparation of derivatives.Key words: Trichodertna lor~gibracl~intwn, leaf spot disease, coffee, fungal metabolites. RCsum6: Le Triclzodertna lorlgibracllial~~~l Rifai aggr. est un champignon qui serait I'antagoniste du champignon Mycerla citricolo,; I'agent qui serait la cause de la maladie des taches sur les feuilles du cafC amCricain. On a Ctudit les metabolites produits lorsqu'on fait une culture liquide du 7: lorzgibrrrcl~intut~~ et on a isole plusieurs nouveaux composCs. On a dCterminC les structures du trichodermolide (2) et du sorbiquinol(3) par une combinaison de techniques spectroscopiques, y compris la RMN du 'H et du I3c, I'IR, I'UV, le DC, la DRO et la spectromitrie de masse, ainsi qui par la preparation de dtrives.

Several new drimane sesquiterpenes, peniopholide [1],3 ß-hydroxypeniopholide [2], 3

Two new tetronic acid derivatives, 5-hydroxyvertinolide (1) and bislongiquinolide (2), have been isolated from the fungus Trichoderma longibrachiatum Rifai aggr., which is antagonistic to the fungus Mycena citricolor, the causative agent of the American leaf spot disease of coffee. The structures were determined by a combination of spectroscopic techniques, including 1H and 13C n.m.r., i.r., u.v., c.d., and mass spectrometry.