O-alkylated analogues (ethyl, propyl, butyl, tert.-butyl) of lysine vasopressin (LVP) and deamino-LVP are partial agonists to LVP in their effect upon activation of adenylate cyclase in porcine kidney membranes. Emax and pD2 values are linearly dependent and both of them are inversely proportional to the overall hydrophobicity of the peptides, expressed in terms of capacity factors in reversed phase high performance liquid chromatography. It is suggested that the increasing hydrophobicity augments the tendency to either a "wrong way" binding, or to a side-side interaction of several peptide ligands bound to a multi-subsite receptor or both. The data circumstantially indicate that the relation between the peptide-receptor interaction and cyclase activation is not a linear one.
Systematic recordings of the EEG during the post-operative period have been rarely reported but Krumpl indicates that changes in the EEG are very common after general surgery and Bagchi et a12 report similar findings following splanchnicectomy. The investigation described in this communication was started after a woman aged 73 failed to regain consciousness following an operation on a fracture under general anaesthesia and was subsequently found to have an infarction extending over a large area of the right cerebral hemisphere.The object of the study was to investigate the occurrence of cerebral disorders in elderly patients following gynaecological surgery. The EEG was, therefore, recorded before and after surgery in a group of elderly patients all of whom were over 64 years of age. These results were later compared with those in similar studies in a group of young and middle aged women who were under 45 years of age.
MATERIAL A N D METHODThe investigation was performed over a period of eight months on patients who were undergoing routine gynaecological procedures. Acute cases were not included but the patients were otherwise unselected.Group A This group consisted of the 22 elderly patients ranging in age from 64 to 84 (mean 72).
Group BThere were 18 younger patients in this group. Their ages ranged from 23 to 45 years (mean 38).The routine of admission was not changed during the period of the investigation. The gynaecologists undertook the routine assessment and investigation of the patients and routine laboratory tests were performed by laboratory assistants.
Normal subjects were loaded with increasing weights (2-6 kg) applied around the ankles. During these conditions stride length increased in relation to velocity. The percentage duration of single support in relation to stride duration increased. Provided the same load was applied around both ankles increase was symmetrical. Consequently there was also an increase of swing as well as a decrease of stance and of double support. The results contrast in all respects to what was found in previous experiments when the load was carried in the hand. During these conditions stride length decreased as well as the duration of single support. The two experimental conditions differed in that with ankle loading the swing phase was loaded while in the other case stance was loaded. The two types of experiment may help to explain why some patients with paretic legs walk with short strides, while others walk with strides that are normal or slightly prolonged.
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