AimOur aim was to study pathogenetically significant markers of sclerosing of hemangiomas in infants upon their exposure to optical radiation in the infrared region of the spectrum by analyzing thermog-raphy and morphology examination results. Materials and methodsThe basis for the thermographic study was our observation KeywordsElectromagnetic radiation of optical spectrum, Remote infrared thermography, Morphology of blood serum, Hemangioma
e14084 Background: The purpose of the study was to determine the etiology of invasive candidiasis (IC) and investigate in vitro activity of caspofungin and azoles for blood isolates of Candida fungi. Methods: We performed a multidisciplinary prospective study of isolates of patients with clinical signs of IC obtained in intensive care units (ICU), oncohematology and oncology departments of hospitals in Rostov-on-Don and Rostov region in 2012-2015. Candida fungi were identified using MALDI-TOF MS; interpretation was performed according to CLSI 2012, M27-S4 criteria. Sensitivity testing was performed using the Sensititre system (Trek Diagnostic Systems, England). Results: 92 Candida isolates were obtained from blood culture: C.albicans - 31.5% (29) and non-albicans - 68.5% (63), including C.tropicalis 30.2% (19), C.parapsilosis 28.6% (18), C.glabrata 19.0% (12), C.krusei 15.9% (10) and C.guilliermondii 6.3% (4). C. albicans were found mostly in oncological departments (44%) compared with ICU – 30% (р=0.003) and departments of oncohematology – 26%. The table demonstrates comparative activities of caspofungin, fluconasole and voriconasole (susceptible – S, intermediate – I, resistant – R) in % to Candida spp. Conclusions: Candida non albicans prevailed among IC pathogens (68.5%), which could be associated with the use of azole antifungal agents for prophylaxis and empirical therapy. Dominating isolates showed decreased activity to caspofungin and azoles. Acquired resistance to azoles was noted for C. parapsilosis and C. albicans. All cases of invasive candidiasis require susceptibility testing for caspofungin and azoles before starting therapy with these agents. [Table: see text]
ВЛИЯНИЕ ХРОНИЧЕСКОЙ БОЛИ РАЗЛИЧНОЙ ЭТИОЛОГИИ НА ОПУХОЛЕВЫЙ ПРОЦЕСС В ЭКСПЕРИМЕНТЕ Жукова Г.В., Шихлярова А.И., Протасова Т.П., Лукбанова Е.А., Ходакова Д.В., Шевченко А.Н., Ващенко Л.Н., Снежко А.В., Триандафилиди Е.И., Быкадорова О.В., Шашкина Л.Ю., Филатова Е.В., Хомутенко И.А. ФГБУ «Национальный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской Федерации, Ростов-на-Дону, galya_57@mail.ru В связи с актуальностью вопроса об изменении течения опухолевого процесса вследствие развития коморбидных состояний проведено изучение влияния хронической боли различной этиологии на динамику роста опухоли и e-mail: продолжительность жизни белых беспородных крыс с перевивной карциномой Герена. Были использованы модели хронической нейрогенной и воспалительной болиодносторонняя перевязка седалищного нерва по G.J. Bennet и введение формалина в область голеностопного сустава. Формирование хронического болевого синдрома сопровождалось резким снижением уровня двигательной активности. Как при введении формалина, так и при односторонней перевязке седалищного нерва наряду с ускорением роста опухоли у части животных наблюдалось увеличение продолжительности жизни по сравнению с максимальным показателем в контрольной группе (более 40% животных). Гибель таких животных наступала, как правило, при более значительных размерах опухоли, чем у крыс контрольной группы. Результаты экспериментального исследования отражают сложную нелинейную связь между процессами, обусловленными хронической болью, индивидуальными особенностями системной регуляции и онкогенезом. Нуждается в выяснении вопрос о механизмах адаптации к злокачественному процессу, способствующей сохранению жизнеспособности организма при продолжающемся росте опухолей и достижению ими крупных размеров. Ключевые слова: нейрогенная боль, воспалительная боль, перевязка седалищного нерва, введение формалина, рост перевивных опухолей, продолжительность жизни. Актуальностьисследования обусловлена широкой распространенностью заболеваний, связанных с развитием нейрогенного и воспалительного болевых синдромов, влияние которых на канцерогенез остается малоизученным. Ранее были показаны ускорение
e19013 Background: Lymphadenopathy presents an important differential diagnostic problem. Thymidine kinase (TK) is an intracellular enzyme catalyzing the conversion of thymidine to thymidine monophosphate in the presence of adenosine triphosphate. TK is the product of certain genes for the progression from G1 through S phase. Determination of serum levels of the first TK isoenzyme is considered to have prognostic significance in malignant proliferation. TK increases significantly in the direct contact of malignant cells with biological fluids such as blood, lymph, or serous effusions, therefore its level changes most significantly in systemic blood diseases. Elevated serum TK has prognostic information and determines a high risk of tumor progression. The purpose of the study was to improve the accuracy of diagnosis of Hodgkin's lymphoma in adolescents, with its differentiation from lymphadenitis. Methods: The study included 34 patients: 13 – lymphadenitis, 21 – Hodgkin's lymphoma. Healthy donors served as a control group. Activity of TK1 (U/L) was determined in the blood serum by radioenzymatic method (in vitro) using a standard test system (Immunotech, BeckmanCoulter, Czech Republic). When TK1 activity was within 10.6-14.8 U/L, adenopathy of unclear etiology was considered lymphadenitis, and in 39.6-45 U/L – Hodgkin's lymphoma. Results: Activity of TK in the blood serum of patients with lymphadenitis (U/L) is shown in Table. Conclusions: Activity of thymidine kinase 1 can be measured as an objective marker for the proliferation of malignant cells, increasing the accuracy of Hodgkin's lymphoma diagnosis in adolescents.[Table: see text]
e15616 Background: The question of the effects of comorbid diseases on oncogenesis has been little studied else. The increase in the frequency of dorsopathies and arthritis with age determines the important of the question about their influence on malignant process. The aim of the research was to study the features of the tumor growth and animal's condition under chronic neurogenic and inflammatory pain. Methods: In experiments on 54 white unbred male rats of 280-390 g, with transplantable Guerin's carcinoma (сG), two experimental models of chronic pain were used - unilateral sciatic nerve ligation (SNL) according to G.J. Bennet (neurogenic pain) and injections of formalin (Fm) into the ankle joint of the back paw (inflammatory pain). Formalin injection is known to be used to form both acute and chronic pain. The dynamics of tumors size, level of motor activity (MAL) in open field test, hematological parameters (by the blood analyzer «Exigo EOS vet», Sweden), adaptation status (AS) by Selye-Garkavi-Kvakina and also the lifespan of the animals (LS) were evaluated. Results: Unlike the unidirectional negative influence of chronic pain known in tumor-bearing animals in the cases of bilateral SNL, two opposite effects were observed with unilateral SNL and the formalin injection. Along with accelerated tumor growth in some animals (up to 62%), increase of LS of more than a third of the rats of the main groups by 3-30% in comparative with maximal LS in the control group was noted. In these cases, often the death of animals occurred with the larger tumors than in the control groups. In the cases of unilateral SNL, a relation between changes in the characteristics of the AS and the LS was noted. In the cases of Fm injections, animals with diverse LS differed in the features of the inflammatory reaction and the dynamics of the MAL. The prognostic value of shifts of the MAL in chronic inflammatory pain and tumor growth is assumed. Conclusions: A nonlinear relationship between the processes caused by chronic pain, oncogenesis, and individual characteristics of systemic regulation was shown. The question about the mechanisms of adaptation to the malignant process, promoting the body's viability in large tumors in conditions of chronic neurogenic and inflammatory pain is of interest.
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