Aim of the study: comprehensive assessment of the rate of aging of the main physiological systems of the body and analysis of the relationships between them. Materials and methods. 188 practically healthy people of various ages (73 men and 115 women) were examined. Methods: anthropometry, echocardiography with Doppler, spirography, ECG with heart rhythm variability analysis, dual X-ray absorptiometry, clinical laboratory biochemical tests. Results. The method of stepwise multiple regression with systematic error correction was used to calculate the formulas of biological age (BA) of the cardiovascular, respiratory, musculoskeletal systems, autonomic regulation, and metabolic age. The obtained formulas make it possible to estimate the rate of aging of the body’s physiological systems with high accuracy (error of 4–5 years). An original method of calculating the integral BA based on the BA of separate body systems is proposed. Conclusion. By calculating the BA of many body systems, it is possible to estimate the rate of aging of these systems and build a human aging profile. This makes it possible to predict the risk of developing one or another age-related pathology and purposefully apply the necessary treatment and preventive measures. A comprehensive assessment of the rate of aging of the body’s physiological systems made it possible to study the heterochrony of aging, the main trajectories of the body’s aging. The connections between the aging of different body systems revealed in our research are important for the development of a strategy for antiaging effects and prevention of age-related pathology. Keywords: biological age, physiological systems, aging profile
Abstract. Determining the biological age of the human arteries is relevant for timely stratification of the risk of developing diseases, prevention, control of individual ageing rate, and geroprotective therapy. To study age-related changes in the echocardiographic examination of the arteries and to develop a formula for estimating the biological age of the human arteries. Echocardiographic examinations of the heart were performed on 188 practically healthy people aged 30 to 79 years (73 men and 115 women), who signed informed consent and had no clinically significant diseases in the anamnesis or at the moment. The study of the carotid and vertebral arteries of the neck was performed on the Xario SSA-660A device from Toshiba (Japan) according to the standard method using a PLT-704SBT 7.5 MHz probe. Based on the data of the study by the method of step-by-step multiple linear regressions, a formula for estimating the biological age of the human arteries was obtained. The multiple correlation coefficient after error correction was a fairly high value of R=0.894 (p˂0.00001). The mean absolute error of age calculation (M±Ϭ) is 5.11±3.51 years. The proposed formula for determining the biological age of the arteries can be used for the early diagnosis of accelerated ageing. Keywords: biological age; ultrasound examination of the main vessels of the neck
The aim: to study the effect of add-on pentoxifylline therapy on the structural and functional indicators of the heart state, endothelial function, quality of life and physical abilities in patients with chronic heart failure with preserved left ventricular ejection fraction. Materials and methods. The indicators of the structural and functional state of the heart, endothelial function, quality of life and physical abilities of patients older than 60 years, who were followed-up in the Department of Cardiology of the State Institution “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, based on 67 case histories, 37 of them were prescribed pentoxifylline as add-on therapy to the standard therapeutic regimen. Statistical data were calculated using modern application packages, in particular SPSS v.22, Statistica 7.0, MedCalc statical software v.11.5.0.0. The significance level was assessed using paired and unpaired Student's t-test with Bonferroni corrections, and the correlation and two-way analysis of variance were performed. Results. A significant additional effect of pentoxifylline treatment on the indicators of maximum blood flow in the forearm microvessels in response to the reactive hyperemia test, which characterizes the ability of the microvessel endothelium to synthesize relaxation factors, was detected. Patients who additionally received pentoxifylline showed significantly better indicators of left ventricular myocardial relaxation and reduction of hypertrophy than those on the standard therapy. There was a significant increase in walking distance in the third year of treatment in the patients who additionally received pentoxifylline. There was no difference in the impact on the quality of life of the patients. Conclusions. The addition of pentoxifylline to the standard therapy in patients with chronic heart failure with preserved left ventricular ejection fraction significantly reduces myocardial hypertrophy, improves diastolic relaxation, increases volumetric blood flow velocity in microvessels mediating reactive hyperemia, which may contribute to further stabilizing the clinical course of the disease and increasing 6-minute walking distance. The presented data are an additional evidence of pathogenetically reasonable therapy with pentoxifylline in patients with chronic heart failure with preserved left ventricular ejection fraction, which allows us to consider this drug as potentially promising for the routine treatment of such patients.
Abstract. The work aimed to develop a mathematical model of the functional age of the respiratory system. 95 practically healthy people aged 29 to 80 were examined. Spirograph parameters were determined on the device "Spirometer MIR Spirobank II" (manufacturer MIR S.r.l., Italy). The most informative indicators of age-related changes in the respiratory system were selected and a formula was obtained that allows to estimate the functional age of this system quite accurately. The average absolute error is 5.28 years. Keywords: functional age; respiratory system
Our research aimed to investigate age-related changes in the functional state of the microvascular endothelium.Матеріали та методи. 390 people were surveyed, divided by age into the following groups: 20-29 (n = 31), 30-39 (n = 22), 40-49 (n = 45), 50-59 (n = 72), 60- 69 (n = 129) and 70-79 years (n = 91). The functional state of the microvascular endothelium was studied by laser Doppler flowmetry (LDF) on the BLF-21D (Transonic Systems Inc, USA) in the middle third of the inner surface of the forearm. The turbidimetric method studied platelet aggregation activity on a two-channel laser platelet aggregation analyzer 23 LA (Biola, Russia). Blood viscosity was determined using a rotary viscometer AKR-2 (Russia) at shear rates of 10-200 s-1 with the calculation of the deformation index (IDE) and erythrocyte aggregation index (IAE). As a result of the research, it was found that there was a statistically significant decrease in the cutaneous rate of skin blood flow volumetric velocity (SBF) at rest and at the peak of post-occlusive reactive hyperemia, as well as a reduction in the recovery time of the CMT to baseline. indicating endothelial dysfunction with ageing from the age of 50-59 years. In persons older than 60 years there is an increase in endothelial dysfunction, which is accompanied by deterioration of hemostasis: increased blood viscosity, increased both spontaneous and induced platelet aggregation activity. Blood viscosity increases statistically significantly from the age of 40. We have drawn the following conclusions: the development of endothelial dysfunction with ageing is characterized by changes in the vasomotor function of the endothelium, its antiplatelet, antiadhesive and antithrombotic properties, which leads to the development of vascular pathology in the elderly. Keywords: functional state of the endothelium; platelet aggregation
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