Background: Women who have anovulatory infertility due to polycystic ovary syndrome (PCOS) rely primarily on medical fertility treatment to conceive. If this treatment fails, the odds of success of conceiving naturally are extremely small, limited by the lack of ovulation and its unpredictability. Whole systems Traditional Chinese Medicine (WS-TCM), which includes acupuncture, Chinese herbs, nutrition and supplements, and lifestyle recommendations, has traditionally been used to prepare the body for pregnancy and to induce ovulation in PCOS patients with anovulatory infertility. Case: This case describes the treatment of a complex anovulatory PCOS patient using a WS-TCM approach to induce ovulation and produce a natural uncomplicated pregnancy after multiple rounds of in vitro fertilization with and without preimplantation genetic screening and also with and without acupuncture were unsuccessful. Results: After 9 unsuccessful frozen embryo transfers, 3 of which with genetically tested euploid embryos, this previously anovulatory patient was able to ovulate, conceive, and carry a healthy pregnancy to term. Conclusions: This case suggests that in challenging cases of infertility in the setting of PCOS, the multifaceted approach of WS-TCM may provide an alternative means to induce ovulation and increase the odds of conceiving.
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