Two children are described with the combination of aplasia cutis congenita (ACC) and transverse limb defects known as Adams-Oliver syndrome. Whereas in the first child the typical features of ACC, syndactyly and transverse nail dystrophy were only mildly expressed and associated defects of the central nervous system and cardiac malformations were absent, the second child suffered from a very severe expression of the syndrome, with a combination of ACC, syndactyly, cutis marmorata telangiectatica congenita and multiple cardiac and central nervous system malformations which resulted in fatal central respiratory insufficiency.
The presence of both cGMP-PK I and VASP, major regulators of the actin cytoskeleton and cell motility, in neointimal tissue suggest that this emerging signal transduction pathway could be a target for the regulation and control of restenosis.
This single-chip RF transceiver provides a complete radio interface between the antenna and the microcontroller. It comprises the analog radio block, digital demodulation including time and frequency synchronization and data buffering. The number of external components is minimized so that only a crystal and 3 decoupling capacitors are required. The bidirectional differential antenna pins are commonly used for RX and TX, therefore, no external antenna switch is needed. Two on-chip low-drop voltage regulators provide the analog and digital 1.8V supply. The SPI interface and the control registers are implemented in 0.36µm technology for data retention in sleep mode when voltage regulators are turned off. The RX and TX signal processing part is implemented using 0.18µm libraries, utilizing the low power consumption and the high density of the technology. The IC is implemented in a 1P 6M 0.18µm CMOS technology with MIM capacitors.
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